منابع مشابه
Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation.
JIP1 is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase-dependent JNK module. Results of earlier work led us to propose a model for JIP1-JNK complex regulation that predicts that under basal conditions, JIP1 maintains DLK in a monomeric, unphosphorylated, and catalytically inactive state. Upon appropriate module stimulation, JNK-JIP1 binding affinity...
متن کاملJnk
What does it do? JNK is important for sending signals from the cell membrane to nuclear transcription factors, increasing their ability to activate transcription. JNK signalling has been implicated in cell growth, oncogenic transformation, cell differentiation and cell death. Stimuli that activate JNK include growth factors, cytokines and just about any kind of stress (see Figure). JNK can be t...
متن کاملJNK at the crossroad of obesity, insulin resistance, and cell stress response
BACKGROUND The cJun-N-terminal-kinase (JNK) plays a central role in the cell stress response, with outcomes ranging from cell death to cell proliferation and survival, depending on the specific context. JNK is also one of the most investigated signal transducers in obesity and insulin resistance, and studies have identified new molecular mechanisms linking obesity and insulin resistance. Emergi...
متن کاملBreakfast and Obesity
Breakfast is a main effective component in a safe dietary lifestyle. Obesity is a social and clinical problem of the present century that is highly prevalent among different societies. The worldwide obesity rate has more than doubled since 1980. Many studies showed that the diet of obese people is insufficient. It is also observed that many obese and overweight people skip breakfast or do not p...
متن کاملObesity and Kidney Disease
The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2002
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20021121-01